Antihistamines

Section 8 - MEDICATION GUIDELINES

8.10 ANTIHISTAMINES

Diphenhydramine (BENADRYL) / Antihistamine

DESCRIPTION

• Inhibits the release of histamine, thereby reducing brocho-constriction and vasodilatation.

INDICATIONS

• Allergic reaction. Dystonic reactions to antiphychotics.

CONTRAINDICATIONS

• Anaphylactic Shock

PRECAUTIONS

• May induce hypotension, headache, Tachycardia, sedation, drowsiness, and /or disturbed coordination.
• Use with caution in patients with asthma and other lower respiratory diseases due to the potential for dyspnea.

DOSAGE

• Adult: 1 mg/ kg up to 50 mg IVP AND refer to the appropriate PRACTICE PARAMETER for specific dosages.
  • For PO administration:
    • 1 mg/kg. Currently supplied in 12.5mg/5ml.
• Pediatrics: Refer to Handtevy System for specific dosages
  • 1 mg/kg up to 50 mg IVP
  • 1mg/kg for PO (12.5mg/5mL)

Famotidine (PEPCID) / H2 Histamine blocker

DESCRIPTION

• Famotidine inhibits histamine at H2 receptor site in the gastric parietal cell, which inhibits gastric acid secretion.

INDICATIONS

• Hives; Allergic reaction; Short term treatment of duodenal and gastric ulcers, management of GERD and erosive esophagitis.

CONTRAINDICATIONS

• Hypersensitivity to the medication
• Renal impairment

PRECAUTIONS

• Hepatic disease, renal disease, elderly

DOSAGE

• Currently supplied in 20mg/50 ml
• Adults: 20mg/ 50ml given at a wide open rate.
• Pediatrics- refer to the Handtevy System.